COMBINATION OF IMMUNE CHECKPOINT MODULATOR AND COMPLEX CONTAINING CELL-PENETRATING PEPTIDE, CARGO MOLECULE, AND TLR PEPTIDE AGONIST FOR MEDICAL USE Russian patent published in 2021 - IPC A61K39/00 A61K47/00 A61K47/66 

FIELD: biochemistry.

SUBSTANCE: proposed invention relates to biotechnology. Disclosed is group of inventions containing combination aimed at preventing or treating cancer, set for preventing or treating cancer, composition, method for treating cancer or initiating, increasing or prolonging the antitumor response in an individual, and method for preventing or treating cancer that provides for combination therapy. In one embodiment of the invention, the combination includes an immune checkpoint modulator and a complex containing a cell-penetrating peptide, at least one antigen or antigenic epitope, and at least one TLR peptide agonist, where the components of the complex are covalently bound, and where at least one TLR peptide agonist is a TLR2 peptide agonist or a TLR4 peptide agonist.

EFFECT: expanded arsenal of tools for prevention or treatment of cancer.

117 cl, 40 dwg, 2 tbl, 23 ex