COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE Russian patent published in 2022 - IPC A61K39/00 A61K47/00 A61K47/66 

FIELD: biotechnology.

SUBSTANCE: described is a group of inventions including a method for generating an immune response in a subject, directed against an antigen or an antigenic epitope dependent on CD4+ helper T cells and/or cytotoxic CD8+ T cells, and a method for generating an immune response in a subject, directed against an antigen or an antigenic epitope limited by class I MHC molecules and/or class II MHC molecules. In one of the variants of implementation, the methods include introducing to the subject (I) a modulator of immune checkpoints and (ii) a complex containing: a) a cell-penetrating peptide; b) at least one antigen or antigenic epitope; and c) at least one TLR peptide agonist, wherein the components a) to c) are covalently bound.

EFFECT: invention expands the range of means for generating an immune response in a subject.

30 cl, 40 dwg, 2 tbl, 23 ex