FIELD: medicine.
SUBSTANCE: what is described is a method for malignant cell elimination with the use of an effective amount of an immunotoxin with a common structure, containing a core unit of gelonin toxin and a one-chained antibody specifically targeted on a malignant cell. According to the invention, the immunotoxin can be an ingredient of a pharmaceutically acceptable composition. The immunotoxin can be delivered to the malignant cell by introduction into a cell of an immunotoxin-expressing construct which is a viral vector.
EFFECT: immunotoxins according to the invention exhibit lower antigenic specificity with preserved biological activity, therefore the method and the composition used in the method have substantial positive properties for a subject requiring such method.
12 cl, 11 dwg, 9 tbl, 6 ex
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