FIELD: medicine.
SUBSTANCE: what is offered is a monoclonal antibody which binds with Aβ Globulomer containing CDRs of a heavy and light chain. There are described: composition for diagnosing Alzheimer's disease, and also a composition and an antibody-based vaccine for preventing or treating Alzheimer's disease. What is disclosed is application of the antibody for preparing a drug for the intended application stated above. There are described: versions of a diagnostic technique for Alzheimer's disease, an antibody-based diagnostic kit for Alzheimer's disease.
EFFECT: use of the invention provides new Aβ Globulomer antibodies which are detected more selectively than common antibodies.
16 cl, 10 dwg, 5 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTISUBSTANCES AGAINST GLOBULOMER Aβ, THEIR ANTIGEN-BINDING PARTS, CORRESPONDING HYBRIDOMAS, NUCLEIC ACIDS, VECTORS, HOST CELLS, WAYS OF PRODUCTION OF MENTIONED ANTISUBSTANCES, COMPOSITIONS CONTAINING MENTIONED ANTISUBSTANCES, APPLICATION OF MENTIONED ANTISUBSTANCES AND WAYS OF APPLICATION OF MENTIONED ANTISUBSTANCES | 2006 |
|
RU2442793C2 |
| IMMUNOGENIC PRODUCTS OBTAINED BASED ON AMINO ACID SEQUENCES OF MUTEIN AMYLOID β (Aβ) AND THEIR APPLICATION METHODS | 2015 |
|
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| SAFE AND FUNCTIONAL HUMANIZED ANTIBODIES | 2011 |
|
RU2607368C2 |
| ADVANCED GLYCATION END PRODUCT (RAGE) RECEPTOR ANTIBODIES AND USING THEM | 2009 |
|
RU2518351C2 |
| HUMANIZED MONOCLONAL ANTIBODY AGAINST Aβ AND ITS USE | 2020 |
|
RU2783528C1 |
| IMPROVED PROTOFIBRIL-SELECTIVE ANTIBODIES AND USE THEREOF | 2007 |
|
RU2429244C2 |
| EPITOPE, SPECIFIC TO AMYLOID BETA OLIGOMER AND ANTIBODIES | 2011 |
|
RU2644335C2 |
| MONOCLONAL BODY AGAINST AMYLOID BETA | 2008 |
|
RU2571856C2 |
| METHOD OF TREATING EYE DISEASES | 2008 |
|
RU2434639C2 |
| TRANSGENIC ANIMALS HAVING MAIN ALZHEIMER'S DISEASE-RELATED DISORDERS | 2004 |
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RU2373707C2 |
