FIELD: chemistry.
SUBSTANCE: invention is an antibody or fragment thereof, having high affinity for protofibril Aβ. The invention also discloses compositions containing the antibody, a method of detecting protofibril Aβ in vitro, as well as use of the antibody.
EFFECT: invention can be effectively used to treat Alzheimer's disease, Down's syndrome, dementia with Lewy bodies and vascular dementia.
28 cl, 19 dwg, 44 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROTOFIBRIL-BINDING ANTIBODIES AND USE THEREOF IN THERAPEUTIC AND DIAGNOSTIC METHODS FOR PARKINSON'S DISEASE, DEMENTIA WITH LEWY BODIES AND OTHER ALPHA-SYNUCLEINOPATHIES | 2011 |
|
RU2555526C2 |
| ANTISUBSTANCES AGAINST GLOBULOMER Aβ, THEIR ANTIGEN-BINDING PARTS, CORRESPONDING HYBRIDOMAS, NUCLEIC ACIDS, VECTORS, HOST CELLS, WAYS OF PRODUCTION OF MENTIONED ANTISUBSTANCES, COMPOSITIONS CONTAINING MENTIONED ANTISUBSTANCES, APPLICATION OF MENTIONED ANTISUBSTANCES AND WAYS OF APPLICATION OF MENTIONED ANTISUBSTANCES | 2006 |
|
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| PRODUCING NON-HUMAN MAMMALIAN ANTIBODIES | 2009 |
|
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| MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF | 2006 |
|
RU2432362C2 |
| ANTIBODY-PRODUCING NON-HUMAN MAMMALS | 2020 |
|
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| ANTIBODY-PRODUCING NON-HUMAN MAMMALS | 2009 |
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| METHODS AND COMPOSITIONS FOR TREATMENT OF AMYLOIDOSES | 2018 |
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RU2746812C1 |
