FIELD: medicine.
SUBSTANCE: isolated antibody is proposed that has an ability to specifically bind to amyloid beta (Aβ), as well as antigenic cyclic peptides capable of eliciting a specific immune response against oligomeric Aβ. Immunoconjugates, compositions, as well as the use of an antibody, an immunoconjugate, and a vaccine composition for Alzheimer's disease treatment or prevention are described. In addition, methods for Alzheimer's disease treatment or prevention, a method and kit for Alzheimer's disease diagnosis, as well as a nucleic acid encoding an isolated antibody are discussed.
EFFECT: invention can find further application in therapy and diagnosis of diseases associated with amyloid beta.
22 cl, 15 dwg, 1 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMPROVED PROTOFIBRIL-SELECTIVE ANTIBODIES AND USE THEREOF | 2007 |
|
RU2429244C2 |
| MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF | 2006 |
|
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| MONOCLONAL BODY AGAINST AMYLOID BETA | 2008 |
|
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|
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| VACCINE AGAINST INTERMEDIATE WITH AMYLOID COAGULATION | 2009 |
|
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| APPLICATION OF MIMOTOPES FOR TREATING BETA-AMYLOIDOSES | 2009 |
|
RU2553345C2 |
| SAFE AND FUNCTIONAL HUMANIZED ANTIBODIES | 2011 |
|
RU2607368C2 |
| COMPOUNDS FOR TREATMENT OF AMYLOIDOSIS | 2009 |
|
RU2491953C2 |
| METHOD OF TREATING EYE DISEASES | 2008 |
|
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| ACTIVE IMMUNISATION FOR CREATING SOLUBLE A-BETA ANTIBODIES | 2004 |
|
RU2390350C2 |
