DERIVATIVES OF CYCLIC ALKYLAMINES AS INHIBITORS OF REACTION BETWEEN MDM2 AND P53 Russian patent published in 2011 - IPC C07D401/14 A61K31/4439 A61K31/4709 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of formula (I) (I), its N-oxide form, addition salt or stereochemically isomeric form, where m equals 0, 1, and m equals 0 denotes a direct bond; n equals 0, 1, 2 or 3, and n equals 0 denotes a direct bond; p equals; t equals 0 or 1, and t equals 0 denotes a direct bond; denotes -CR⁸=C<, and the dotted line denotes a bond, where R⁸ denotes hydrogen; R¹ and R² denotes hydrogen; R³ and R⁴ denote hydrogen; R⁵ denotes hydrogen; R⁶ and R⁷ each is independently selected from hydrogen or C_1-6alkyl; Z denotes a radical selected from (a-1) (a-2) (a-4), where R¹⁰ and R¹¹ are each independently selected from hydrogen, hydroxy, C_1-6 alkylcarbonyl, C_1-6 alkylcarbonyloxy C_1-6 alkyl, C_1-6 alkyloxycarbonyl, C_1-6 alkylcarbonyloxy, hydroxy C_1-6 alkyl. The invention also describes a pharmaceutical composition for treating cancer, based on the compound of formula I, as well as a method of preparing said composition and use of the compound of formula I, combination thereof with an anticancer agent and preparation method thereof.

EFFECT: improved properties of compounds.

14 cl, 6 ex, 2 tbl