MDM2 AND P53 INTERACTION INHIBITORS Russian patent published in 2011 - IPC C07D401/12 C07D405/12 C07D471/04 A61K31/4409 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of formula (I) and pharmaceutically acceptable salt thereof, where m denotes a direct bond; n equals 0, 1, 2, 3 or 4 and n equals zero indicates a direct bond; p equals 1; s denotes a direct bond; t denotes a direct bond; R¹ and R² each independently denotes hydrogen; A denotes a radical selected from , where R⁴ and R⁵ are each independently selected from hydrogen or C_1-6alkyloxy; Z denotes a radical (b-2), where R⁶ and R⁷ each independently denotes hydrogen. The invention also describes a pharmaceutical composition for treating cancer and preparation method thereof, based on compounds of formula I, use of these compounds to obtain a medicinal agent, as well as a method of producing said compounds.

EFFECT: novel compounds which can be used as p53-MDM2 interaction inhibitors are obtained and described.

10 cl, ex, 2 tbl