SPIRO OXINDOLE MDM2 ANTAGONISTS Russian patent published in 2015 - IPC C07D487/10 A61K31/407 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of organic chemistry, namely to heterocyclic compounds of the general formula or to their pharmaceutically acceptable salts, where R^1a, R^1b, R^1c and R^1d are independently selected from the group, consisting of hydrogen and halogen; R² is selected from the group, consisting of phenyl, substituted with 1 or 2 halogen atoms; R³ is selected from the group, consisting of C₁-C₅alkyl and (C₅cycloalkyl)C₁alkyl; R⁴ represents hydrogen; R⁵ represents , where each of: R^12a, R^12b, R^12c and R^12d represents hydrogen; R¹³ represents hydrogen; R¹⁴ is selected from the group, consisting of hydrogen and C₁-C₆alkyl; Z is selected from the group, consisting of -OR¹⁵ and -NR^16aR^16b; or Z and R¹⁴ together form a carbonyl group; R¹⁵ and R^16b represent hydrogen; R^16a represents -SO₂R^16c; R^16c represents C₁alkyl; o equals 1 or 2; p equals 1 or 2; X represents NR'; Y represents NR"; R' and R" represent hydrogen; and represents a single or a double bond. The invention also relates to a pharmaceutical composition based on the formula I compound, methods of cancer treatment and a set based on the formula I compound.

EFFECT: obtained are novel heterocyclic compounds, useful in the treatment of hyperproliferative disorders.

17 cl, 32 dwg, 32 tbl, 11 ex