METHOD OF IN VITRO DETERMINATION OF PROGNOSIS OF DISEASE DEVELOPMENT IN PATIENT WITH CANCER AND METHOD OF IN VITRO MONITORING EFFECT OF THERAPY ADMINISTERED TO PATIENT WITH CANCER Russian patent published in 2011 - IPC C12Q1/48 C12N9/12 A61P35/00 

FIELD: medicine.

SUBSTANCE: method of determining prognosis of disease development in patient with cancer includes estimation of level of choline kinase alpha gene expression in cancer tissue sample, taken from patient, and comparison of obtained value with value, corresponding to one or more samples of normal non-cancer tissue. Higher level of choline kinase alpha gene expression is used to differentiate patients with worse prognosis of disease development. Method of in vitro monitoring of anti-cancer therapy effect is realised by estimation of level of choline kinase alpha gene expression in cancer tissue sample, taken from patient, who is introduced anti-tumour agent, and comparison of obtained value with value, corresponding to one or more samples of normal non-cancer tissue. Efficient therapy reduces levels of choline kinase alpha gene expression or causes reversing the effects of high expression of said gene.

EFFECT: invention makes it possible to determine prognosis of disease development in patient with cancer or carry out monitoring of anti-cancer therapy in patient in efficient way.

6 cl, 47 dwg, 3 tbl, 11 ex