FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and concerns DNA repair inhibitors for cancer therapy. Substance of the invention involves establishing the fact that base excision repair inhibition is lethality-selective in cells used to be defect in double-stranded DNA repair dependent on homology recombination Herewith, provided are methods and agents for treating cancerous diseases being double-stranded DNA repair defect dependent on homology recombination, with using PARP inhibitors, particularly a PARP inhibitor represents phthalizine-1 (2H)-one.
EFFECT: development of a drug used for treating cancer being double-stranded DNA repair defect dependent on homology recombination.
17 cl, 18 dwg
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