FIELD: biotechnology.
SUBSTANCE: group of inventions is described, including a method for prediction of increase in sensitivity of tumour cells growth to Wnt inhibitor, an assay kit for cancer patient selection, for whom the favorable or not outcome can be achieved from therapeutic administration of a Wnt inhibitor, according to prediction. The prediction method includes the steps of: biomarker level determination in a tumour cell sample obtained from a subject; comparison of the biomarker level in a tumour cell sample withthe control biomarker level; selection of a subject who, according to the prediction, should have a favorable outcome from therapeutic administration of a Wnt inhibitor.
EFFECT: invention expands the arsenal of methods for tumour cells growth prediction.
25 cl, 8 dwg, 10 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MARKERS ASSOCIATED WITH WNT INHIBITORS | 2014 |
|
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| AGENTS LINKING FRIZZLED RECEPTOR AND THEIR USE | 2009 |
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RU2579897C2 |
| METHOD FOR TISSUE REGENERATION STIMULATION | 2007 |
|
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| MEDICAL PREDICTION AND PREDICTION OF TREATMENT RESULTS USING ACTIVITY OF MULTIPLE CELL SIGNALING PATHWAYS | 2014 |
|
RU2718647C2 |
| WNT ANTAGONISTS AND METHODS OF TREATING AND TESTING | 2011 |
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RU2593947C2 |
| IMPROVED DIFFERENTIATION METHOD | 2017 |
|
RU2772435C2 |
| THERAPY OF INTESTINAL ADENOMA AND/OR ADENOCARCINOMA BY INHIBITING NOTCH ACTIVATION | 2005 |
|
RU2392961C2 |
| PEPTIDES IN COMBINATION WITH IMMUNE CHECKPOINT INHIBITORS FOR USE IN TREATING CANCER | 2020 |
|
RU2826955C2 |
| MONOCLONAL ANTIBODY AGAINST FZD10, ITS USE | 2017 |
|
RU2765431C2 |
| MIMETICS WITH REVERSE CONFIGURATIONS AND METHODS OF THEIR ADMINISTRATION | 2004 |
|
RU2342387C2 |
