FIELD: chemistry.
SUBSTANCE: invention relates to methotrexate derivatives which contain a protein-binding group and can be enzymatically split in the body such that an active compound or a low-molecular derivative of the active compound can be released. Also disclosed is a method of producing methotrexate derivatives, use thereof and pharmaceutical compositions containing methotrexate derivatives.
EFFECT: improved method.
21 cl, 15 dwg, 1 tbl, 8 ex
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