HEPTAPEPTIDE AMIDES FOR THE TREATMENT OF HMGB1-DEPENDENT DISEASES Russian patent published in 2021 - IPC C07K7/06 A61K38/08 A61P11/00 A61P19/02 

Abstract RU 2760133 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I): H-Tyr-D-Ala-Gly-Phe-Leu-Arg-Arg-Z, where Z is -NR1R2, where R1 and R2 are the same or different and represent hydrogen or lower an alkyl chain containing up to 4 carbon atoms, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions based on it for use in the treatment of an HMGB1-dependent inflammatory or autoimmune disease.

EFFECT: improvement of formula compound.

7 cl, 5 tbl, 6 ex

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RU 2 760 133 C1

Authors

Karkishchenko Vladislav Nikolaevich

Skvortsova Veronika Igorevna

Pomytkin Igor Anatolevich

Karkishchenko Nikolaj Nikolaevich

Dates

2021-11-22Published

2021-04-22Filed