METHOD OF INDIVIDUAL RECOVERY OF FUNCTIONAL ACTIVITY OF ADRENAL CORTEX IN PATIENTS WITH SOMATIC DISEASES WITH LONG HISTORY OF GLUCOCORTICOSTEROID THERAPY Russian patent published in 2012 - IPC G01N33/48 A61K35/55 A61P5/38 

FIELD: medicine.

SUBSTANCE: method of individual recovery of functional activity of adrenal cortex in patients with somatic diseases with long history of glucocorticosteroid (GCS) therapy includes detection of iatrogenic adrenal insufficiency by value of indices of cortisol in blood, urine and on the basis of indices of functional test, which consists of intramuscular introduction of 1 mg synacthen-depot, synacthen-depot being introduced in the morning and determined in day urine: free, conjugated and general cortisol, in blood, obtained in the morning hours: ACTH, dehydroepiandrosteron-sulfate (DHEA-s), aldosteron, glucose, potassium, sodium, stimulation of synacthen-depot is carried out step-by-step with simultaneous reduction of taken doses of glucocorticosteroids; if indices of hormones in blood and urine decrease on the 3-rd or 5-th day by more than 50% from the lower norm boundary, further stages of medication injections are carried out after different time intervals from 6 to 5 months depending on the content of said indices in blood and urine without injection of synacthen-depot during dynamic examination of patient, further stages are realised with additional determination of cortisol content in blood 1 hour after synacthen-depot injection, if level of cortisol in vblood is higher than 500 nmol/l an hour after the injection, with normal excretion of free cortisol on the 3-rd or 5-th day, normal content of electrolytes, glucose in blood with satisfactory patient's condition, intake of glucocorticosteroids is cancelled.

EFFECT: invention makes it possible to avoid clinical manifestations of cessation syndrome and exacerbation of main and accompanying diseases in patients.

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