METHOD OF PAIN MANAGEMENT AND NEURON TISSUE INFLAMMATION TREATMENT WITH USING IL-31 ANTAGONISTS Russian patent published in 2012 - IPC A61K38/02 A61K39/395 A61P1/00 A61P17/02 A61P19/02 A61P25/04 A61P29/00

Abstract RU 2440130 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine. A method involves application of IL-31 antagonist for IL-31 induced signal transduction inhibition in dorsal root ganglion cells. The IL-31 antagonist inhibits IL-31 polypeptide binding containing amino acid residues 27-164 SEQ ID NO:2 with its heterodimeric receptor containing IL-31RA and OSMR-beta. The antagonist represents a humanized monoclonal antibody or a chimeric antibody.

EFFECT: use of the method effectively relieves inflammation, pain and itching.

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RU 2 440 130 C2

Authors

Jao Jueh

Bilsboro Dzhanin

Krejsa Sesil'

Zukerman Linda

Rogge Mark

Dates

2012-01-20—Published

2007-01-10—Filed