FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of pharmaceutics and deals with pharmaceutical composition for treatment or prevention of constipation, which contains bicyclic compound of formula 
and polyol and/or ester of fatty acid and alcohol, selected from propylene glycol, polyethyldenglycol and C1-C6 monovalent alcohol, method of formula (1) bicyclic compound stabilisation by mixing said compound with polyol and/or ester of fatty acid and alcohol, composition in soft gelatin capsule, whose envelope contains gelatin and polyol, containing formula (I) compound and pharmaceutically acceptable carrier, and method of formula (I) compound stabilisation by mixing formula (1) compound with pharmaceutically acceptable carrier and enclosing obtained liquid mixture into soft gelatin capsule, whose envelope contains gelatin and polyol as plasticiser.
EFFECT: composition possesses high stability.
35 cl, 3 tbl, 3 ex
