FIELD: medicine.
SUBSTANCE: oncologic mutations, associated with hereditary breast cancer are detected by determination of complete nucleotide sequence of coding part of BRCA1 gene. Amplification of coding part of BRCA1 gene by means of 28 pairs of synthetic oligonucleotides is performed with further sequencing amplification products.
EFFECT: invention makes it possible to detect mutations, associated with hereditary forms of breast cancer, with high accuracy and reliability.
1 dwg, 5 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR BRCA1 AND BRCA2 GENES EXONS NUCLEOTIDE SEQUENCE DETERMINATION | 2015 |
|
RU2612894C1 |
| METHOD FOR MOLECULAR-GENETIC DIAGNOSIS OF HEREDITARY BREAST CANCER | 2019 |
|
RU2702755C1 |
| METHOD FOR HUMAN GENOTYPE DETERMINATION BY 2579 GENE BRCA1 (rs4986850) POSITION POLYMORPHISM | 2010 |
|
RU2445371C1 |
| METHOD FOR HUMAN GENOTYPE DETERMINATION BY 5382 GENE BRCA1 (5382insC) POSITION POLYMORPHISM | 2010 |
|
RU2445368C2 |
| METHOD FOR HUMAN GENOTYPE DETERMINATION BY 185 GENE BRCA1 (185delAG) POSITION POLYMORPHISM | 2010 |
|
RU2445369C2 |
| METHOD OF DIFFERENTIATED USE OF DNA SEQUENCING DATA FOR PATIENTS AFTER KIDNEY TRANSPLANTATION | 2022 |
|
RU2803796C1 |
| METHOD FOR HUMAN GENOTYPE DETERMINATION BY 4343 GENE BRCA1 (rsL799950) POSITION POLYMORPHISM | 2010 |
|
RU2445373C1 |
| METHOD OF PREDICTING THE RISK OF OVARIAN CANCER | 2015 |
|
RU2599502C1 |
| METHOD FOR PREDICTION OF RISK OF MALIGNANT DISEASES OF MAMMARY GLAND AND/OR OVARIES IN PATIENTS AFTER KIDNEY TRANSPLANTATION | 2023 |
|
RU2821583C1 |
| METHOD FOR PREDICTION OF GENETIC PREDISPOSITION TO BREAST CANCER | 2012 |
|
RU2522501C1 |
