FIELD: biotechnology.
SUBSTANCE: what is described is a method for prediction of risk of malignant diseases of mammary gland and ovaries in patients after kidney transplantation. Method involves venous blood sampling from a patient not earlier than 60 days after kidney transplantation, extraction of DNA from the obtained sample, preparation of DNA libraries, DNA sequencing. In case of detection in patients after kidney transplantation BRIP1 gene mutation variant in heterozygous state in 2nd exon of 20, leading to replacement of amino acid lysine with asparagine in position 14 – p.Lys14Asn, missense mutation, high risk of malignant diseases of mammary gland or ovaries is predicted.
EFFECT: detection of predisposition to breast cancer and ovarian cancer in patients after kidney transplantation.
4 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DIFFERENTIATED USE OF DNA SEQUENCING DATA FOR PATIENTS AFTER KIDNEY TRANSPLANTATION | 2022 |
|
RU2803796C1 |
| METHOD FOR IDENTIFYING RECESSIVE FACTORS OF GENETIC PREDISPOSITION TO BREAST CANCER | 2013 |
|
RU2535157C1 |
| METHOD FOR MOLECULAR-GENETIC DIAGNOSIS OF HEREDITARY BREAST CANCER | 2019 |
|
RU2702755C1 |
| DETERMINATION OF CANCER SUSCEPTIBILITY BY IDENTIFICATION OF GENOTYPIC COMBINATIONS OF SPECIFIC VERSIONS OF CYP1B1, BRCA2 AND CHEK2 GENES | 2006 |
|
RU2470998C2 |
| DIAGNOSTIC METHOD OF PREDISPOSITION TO BREAST CANCER IN RUSSIAN POPULATION BASED ON PCR-RFLP | 2018 |
|
RU2723585C2 |
| METHOD OF PREDICTING THE RISK OF OVARIAN CANCER | 2015 |
|
RU2599502C1 |
| METHOD FOR BRCA1 AND BRCA2 GENES EXONS NUCLEOTIDE SEQUENCE DETERMINATION | 2015 |
|
RU2612894C1 |
| METHOD OF PREDISPOSITION TO ONCOPATHOLOGY DETERMINATION | 2018 |
|
RU2694231C1 |
| METHOD FOR PREDICTION OF RISK OF RENAL CELL CARCINOMA | 2019 |
|
RU2721709C1 |
| SET OF SYNTHETIC OLIGONUCLEOTIDES FOR DETERMINATION OF NUCLEOTIDE SEQUENCE OF CODING PART OF BRCA1 GENE AND DETECTION OF MUTATIONS, ASSOCIATED WITH HEREDITARY FORMS OF BREAST CANCER | 2010 |
|
RU2440415C1 |
