FIELD: medicine, immunology.
SUBSTANCE: group of inventions relates to medicine in particular to immunology and can be used for treatment of phologistic or autoimmune diseases associated with CD40-expressing cells of the patient, heterozygous or homozygous concerning FcγRIIIa-158F (genotype V/F or F/F); the invented medications include variants of the monoclonal antibodies to CD40 which bind with the epitope which can bind with the monoclonal antibody CHIR-12.12; the invented methods include the identification of a human patient suffering from phologistic or autoimmune diseases to be cured by the antibody to CD40 which are resistant to treatment by rituximab, by means of the determination of the genotype FcγRIIIa-158F (genotype V/F or F/F) with application of the biological specimen attained from this human patient.
EFFECT: application of the method allows to cure phologistic or autoimmune diseases resistant to rituximab.
41 cl, 1 tbl, 14 dwg, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| USING ANTI-CD40-ANTIBODIES | 2008 |
|
RU2491095C2 |
| ANTI-CD40-ANTIBODIES AND METHODS OF APPLICATION | 2012 |
|
RU2609647C2 |
| HUMANISED ANTI-CD40-ANTIBODIES AND METHODS OF APPLICATION THEREOF | 2006 |
|
RU2407544C2 |
| METHOD AND COMPOSITION FOR REDUCTION OF MICROMOLECULE AGGREGATION UNDER PHYSIOLOGICAL CONDITIONS | 2009 |
|
RU2563823C2 |
| MONOCLONAL ANTI-CD20-ANTIBODY | 2006 |
|
RU2415871C2 |
| MONOCLONAL ANTIBODIES AGAINST IL-21 OF HUMAN BEING | 2008 |
|
RU2504552C2 |
| POLYPEPTIDES CONTAINING Fc-SECTION THAT DISPLAY INCREASED EFFECTOR FUNCTION OWING TO VARYING FUCOSYLATION LEVEL AND THEIR APPLICATIONS | 2010 |
|
RU2583298C2 |
| DECREASING B-CELL COUNT WITH USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES | 2006 |
|
RU2423381C2 |
| ANTIBODIES TO CD40 FOR USE IN THE TREATMENT OF SJOGREN'S SYNDROME | 2018 |
|
RU2790558C2 |
| METHODS AND COMPOSITIONS FOR AUTOIMMUNE AND INFLAMMATORY DISEASES TREATMENT | 2012 |
|
RU2639540C2 |
