FIELD: biotechnologies.
SUBSTANCE: claimed invention discloses the attenuation of post-translational fucosylation of the molecule containing a modified Fc-section. The claimed process comprises the Fc-section modification, molecule-candidate expression, evaluation of the ratio between the glycosylation of oligosaccharides with the high content of mannose and the glycosylation of complex oligosaccharides and identification of the molecule-candidate as a suitable one at the ratio over 0.2. The proposed invention can be used in medicine.
EFFECT: higher efficiency of purification.
15 cl, 95 dwg, 35 tbl, 7 ex
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Authors
Dates
2016-05-10—Published
2010-10-07—Filed