POLYPEPTIDES CONTAINING Fc-SECTION THAT DISPLAY INCREASED EFFECTOR FUNCTION OWING TO VARYING FUCOSYLATION LEVEL AND THEIR APPLICATIONS Russian patent published in 2016 - IPC C12P21/08 

Abstract RU 2583298 C2

FIELD: biotechnologies.

SUBSTANCE: claimed invention discloses the attenuation of post-translational fucosylation of the molecule containing a modified Fc-section. The claimed process comprises the Fc-section modification, molecule-candidate expression, evaluation of the ratio between the glycosylation of oligosaccharides with the high content of mannose and the glycosylation of complex oligosaccharides and identification of the molecule-candidate as a suitable one at the ratio over 0.2. The proposed invention can be used in medicine.

EFFECT: higher efficiency of purification.

15 cl, 95 dwg, 35 tbl, 7 ex

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RU 2 583 298 C2

Authors

Dzhonson Lesli S.

Rejni Godfri Dzhouna Anderson

Lerner Laura

Gorlatov Sergej

Dates

2016-05-10Published

2010-10-07Filed