FIELD: biotechnology.
SUBSTANCE: invention relates to an isolated antibody against RhoB, a fragment thereof, a composition containing it, as well as to a method for suppression of an inflammatory and/or autoimmune disease mediated by B cells and to a method of treatment of a condition or disorder associated with elevated levels of serum immunoglobulin for a subject in need, with its use. An isolated peptide for production of the above antibody is also disclosed, as well as a conjugate and a composition containing it.
EFFECT: invention can effectively suppress an inflammatory or autoimmune disease mediated by B cells.
19 cl, 10 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMAN VISTA ANTIBODIES AND THEIR APPLICATION | 2017 |
|
RU2746994C2 |
| APPLICATION OF ANTI-CD40-ANTIBODIES | 2006 |
|
RU2442606C2 |
| ANTIBODIES AGAINST EOTAXIN 2, WHICH RECOGNIZE ADDITIONAL CCR3-BINDING CHEMOKINES | 2015 |
|
RU2705255C2 |
| KIR3DL2 BINDING AGENTS | 2013 |
|
RU2682449C2 |
| SUBSTANCES AND METHODS FOR USE IN THE PREVENTION AND/OR TREATMENT OF HUNTINGTON'S DISEASE | 2015 |
|
RU2742493C2 |
| BINDING MOLECULES SPECIFIC TO IL-21, AND FIELD OF APPLICATION THEREOF | 2015 |
|
RU2708336C2 |
| ANTIBODIES AGAINST OX40 AND METHODS OF THEIR APPLICATION | 2012 |
|
RU2562874C1 |
| HUMANIZED MONOCLONAL ANTIBODY RAISED AGAINST AILIM, CO-STIMULATING MOLECULE FOR SIGNAL TRANSFER AND ITS PHARMACEUTICAL APPLYING | 2001 |
|
RU2262511C2 |
| THERAPEUTIC BINDING MOLECULES | 2002 |
|
RU2328506C2 |
| PEPTIDE OR PEPTIDE COMPLEX BINDING TO alpha2- INTEGRIN, METHODS FOR PRODUCTION AND USE THEREOF | 2011 |
|
RU2588668C2 |
