FIELD: chemistry.
SUBSTANCE: invention refers to the compounds of formula I 
in which R1 is chosen from the group including: H; alkyl; alkylenearyl and pyridin; R2 is chosen from the group including: cycloalkyl; aryl; CO-NH-cycloalkyl; CO-NH-aryl either unsubstituted or substituted with the help of halogen, CF3; SO2-aryl either unsubstituted or substituted with the help of alkyl; or in which R1 and R2 together form a 5- or 6-membered ring that does not need to contain 1 additional nitrogen heteroatom and that may also be substituted with the help of aryl; and that may also contain a carbonyl group; and that may also be condensed with aryl; R3 and R4 denote H; and acid additions to their physiologically acceptable salts. Invention also refers to a pharmaceutical composition, to the way of production of the formula I compound, to application of the formula I compound, and to the way of treatment or prevention of fatty degeneration, type II diabetes, metabolic syndrome and associated and/or secondary diseases or pathologic conditions endured by mammals.
EFFECT: production of new bioactive compounds that inhibit the isoenzyme of hydroxy citric acid II (hCA II).
11 cl, 11 ex, 3 tbl
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