FIELD: organic chemistry, medicine, endocrinology, pharmacy.
SUBSTANCE: invention describes novel derivatives of hexahydrodiazepinone of the general formula (I): 
or their pharmaceutically acceptable salts wherein Ar represents phenyl substituted with one-three halogen atoms; R1 means hydrogen atom, (C3-C6)-cycloalkyl possibly substituted with hydroxy-group, halogen atom, (C1-C10)-alkoxycarbonyl or phenyl-(C1-C3)-alkoxy-group; R4 means hydrogen atom, (C1-C10)-alkyl optionally substituted with: (a) phenyl that can be substituted with halogen atom, (C1-C3)-alkyl, halogen-(C1-C3)-alkyl, halogen-(C1-C3)-alkoxy-group; (b) hydroxy-group; (c) (C3-C6)-cycloalkyl; (d) phenyl-(C1-C3)-alkoxy-group; (e) biphenyl; (f) pyridyl; (g) 1-oxido-pyridinyl; (i) pyrazolyl; R5 means hydrogen atom or (C1-C10)-alkyl; R8 and R9 mean hydrogen atom. Also, invention relates to a pharmaceutical composition containing these compounds and using novel compounds for preparing a medicinal agent used in treatment of non-insulin dependent diabetes mellitus.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
16 cl, 2 tbl, 9 ex
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