TARTRATE DERIVATIVES APPLIED AS BLOOD COAGULATION FACTOR IXA INHIBITORS Russian patent published in 2012 - IPC C07D217/22 C07D235/30 C07C235/14 C07C257/18 A61K31/472 A61K31/4184 A61K31/165 A61P7/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula

and/or to all isomer forms of a compound of formula I, and/or to mixtures of these forms in any proportions, and/or to physiologically acceptable salts of the compound of formula 1, wherein R1 represents 1) -(C₆-C₁₄)-aryl-Z, wherein Z represents amino group, aminomethylene or amidino group, and wherein aryl is unsubstituted, 2) Het-Z, wherein Z represents amino group, aminomethylene or amidino group, and wherein Het is selected from benzimidazolyl and isoquinolinyl, and Het is unsubstituted or monosubstituted by group T, R2 and R4 are identical, and each represents hydrogen atom, R3 represents 1) -(C₀)-alkylene-(C₆-C₁₄)-aryl, wherein aryl is unsubstituted or monosubstituted by group T, 2) -(C₀)-alkylene-(C₆-C₁₄)-aryl-Q-(C₆-C₁₄)-aryl, wherein both aryls are unsubstituted, 3) -(C₀-C₄)-alkylene-(C₆-C₁₄)-aryl-p-Het, wherein aryl and Het in each case are unsubstituted, and Het represents piperidinyl, Q represents a covalent bond or -O-, T represents 1) halogen, 2) -(C₁-C₆)-alkyl wherein alkyl is unsubstituted, 3) -(C₃-C₈)-cycloalkyl or 4) -NO₂, R5 and R6 are identical, and each represents hydrogen atom. Also, the invention refers to the use of the compound of formula I for preparing a drug.

EFFECT: there are prepared new compounds effective as blood coagulation factor IXA inhibitors.

6 cl, 2 tbl, 5 ex