PHARMACEUTICAL COMPOSITIONS GLP-1 Russian patent published in 2012 - IPC A61K38/02 A61K33/30 A61K33/34 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmacology and represents a pharmaceutical composition containing the GLP-1 [Aib^8,35]hGLP-1 (7-36)NH₂ analogue prepared together with a pharmaceutically acceptable salt of said analogue or a mixture of salt of said analogue and the analogue, said composition additionally contains a bivalent metal and/or a bivalent metal salt with the molar ratio of said GLP-1 analogue and said bivalent metal and/or bivalent metal salt in said pharmaceutical composition makes approximately 5.4:1 to approximately 1.5:1; wherein said bivalent metal represents zinc or copper, and wherein the range of the molar ratios of said salts (Aib^8.35)hGLP-1 (7-36)NH₂ and the GLP-1 peptide analogues makes approximately 0.5:1 to approximately 10:1.

EFFECT: invention provides easy and reproducible introduction of the composition to a patient, as well as reduction or elimination of undesired side effects.

11 cl, 9 ex, 7 tbl, 12 dwg