PRODRUGS CONTAINING EXENDIN CONJUGATE-LINKER Russian patent published in 2016 - IPC A61K38/17 A61K47/48 

FIELD: medicine.

SUBSTANCE: invention relates to an exendin prodrug, which is characterised by a chemical structure including an exendin fragment, linker fragment and hydrogel, connected with linker fragment. Hydrogel consists of frame fragments with quaternary carbon of formula C(A-Hyp)₄, where A is -(CH₂)_n1(OCH₂CH₂)_nX₁-; n1=1-2; n=5-50; X₁ is a chemical functional group covalently bonding A and Hyp. Hyp consists of 5 to 32 lysine residues. Frame fragments of hydrogel are cross-linked by cross-linking fragments based on poly(ethylene glycol). Invention also relates to methods of producing prodrugs and to a pharmaceutical composition containing prodrug.

EFFECT: prolonged action of prodrug and prolonged half-life.

18 cl, 20 ex, 1 dwg, 1 tbl