FIELD: pharmaceutical industry, medicine.
SUBSTANCE: invention relates to compounds of formula I 
, wherein A, L, Y, and k are as defined in specification. Compounds of formula I have value pharmacological activity, in particular potent antithrombosis action and are useful in treatment and prophylaxis of cardiovascular diseases such as thromboembolia. They represent also reversible inhibitors of factor X and factor VIIa (blood coagulation enzymes). Also disclosed are methods for production of compounds I, uses thereof, in particular as active ingredients in pharmaceutical compositions, as well as medicines containing the same.
EFFECT: new pharmaceutical compositions for treatment and prophylaxis of cardiovascular diseases.
10 cl, 50 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INHIBITORS OF FACTOR VIIA | 2000 |
|
RU2248359C2 |
| DERIVATIVES OF (THIO)UREA INHIBITING VIIa FACTOR, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION | 2001 |
|
RU2286337C2 |
| AZAINDOL DERIVATIVES AS FACTOR Xa INHIBITORS | 2004 |
|
RU2330853C2 |
| INHIBITORS OF VIIA FACTOR | 1999 |
|
RU2223967C2 |
| CARBOXYLIC ACID DERIVATIVES CONTAINING 2,5,7-SUBSTITUTED OXAZOLE PYRIMIDINE RING | 2011 |
|
RU2560876C2 |
| HETEROARYL-SUBSTITUTED AMIDES CONTAINING SATURATED BINDING GROUP AND USE THEREOF AS PHARMACEUTICAL AGENTS | 2006 |
|
RU2412181C2 |
| 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES | 2011 |
|
RU2554874C2 |
| CARBOXYLIC ACID DERIVATIVES, HAVING OXAZOLE[4,5-D]PYRIMIDINE RING | 2012 |
|
RU2609003C2 |
| SUBSTITUTED DERIVATIVES OF IMIDAZOLIDINE, METHOD FOR PREPARING AND PHARMACEUTICAL PREPARATION | 1998 |
|
RU2239641C2 |
| FLOW-THROUGH REDOX ELEMENT FOR ELECTRIC POWER ACCUMULATION AND ITS APPLICATION | 2016 |
|
RU2722695C2 |
