GDF8 ANTIBODIES AND USE THEREOF Russian patent published in 2012 - IPC C07K16/22 C12N5/10 C12N15/13 C12N15/63 G01N33/53 A61K39/395 A61P21/00 

Abstract RU 2447084 C2

FIELD: chemistry, pharmaceutics.

SUBSTANCE: present invention refers to biotechnology and immunology. There are offered: a monoclonal antibody or its fragment specifically bound with GDF8 and not bound with BMP11, a polynucleotide coding it, an expression vector and a host cell for antibody expression. There are studied: a method for producing the GDF8-specific antibody, a method for GDF8 presence test, a method of treating a GDF8-associated disorder.

EFFECT: use of the invention provides the new GDF8-specific antibodies that can find further application in the therapy of the GDF8-mediated diseases.

22 cl, 33 dwg, 8 tbl, 7 ex

Similar patents RU2447084C2

Title Year Author Number
POLYPEPTIDES FOR BONDING WITH "RECEPTOR OF ADVANCED GLYCATION ENDPRODUCTS", THEIR COMPOSITIONS AND METHODS, WHICH THEY TAKE PART IN 2010
  • Khuber, Jokhen
  • Blansh, Fransis
  • Dabdubi, Tarik
  • Subrie, Fab'Enn
  • Fokken, Ingo
  • Kruip, Jokhen
  • Kheermajer, Katrin
  • Lange, Kristian
RU2558301C2
RECOVERED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT (VERSIONS), METHOD OF TREATING hTNFα-MEDIATED DISEASES WITH MEDIATION THEREOF (VERSIONS), PHARMACEUTICAL COMPOSITION, RECOMBINANT HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT, RECOVERED NUCLEIC ACID (VERSIONS) 2005
  • Allen Debora Dzh.
  • Vogen Tristan Dzh.
  • Kajmaksalan Zera
  • Labkovski Boris
  • Makginess Brajen T.
  • Mankovich Dzhon Eh.
  • Roberts Ehndrju Dzh.
  • Sakorafash Pol'
  • Sehlfeld Dzhokhen G.
  • Uajt Majkl
  • Uilton Ehlison Dzh.
  • Khugenbum Khendrikus R. Dzh. M.
  • Shoehnkhaut Dehvid
RU2458704C9
BINDING MOLECULES SPECIFIC FOR ASCT2, AND THEIR USE 2016
  • Por Nabendu
  • Borrok Martin Dzh., Iii
  • Chovdkhuri Partkha
  • Mikelotti Emil F.
  • Tajs Devid A.
  • Khollingsvort Robert E.
  • Chan Chien-In
RU2710194C2
BINDING MOLECULES SPECIFIC TO IL-21, AND FIELD OF APPLICATION THEREOF 2015
  • Ettinger Ketrin
  • Karnell Dzhodi
  • Damshroder Melissa
  • Chaudkhari Parta
  • Syao Syaodun
  • Tsuj Pin
  • Varkej Rina
  • Drabik Stejsi
  • Karter Laura
  • Kherbst Ronald
  • Du Tsun
  • Najman Brajan Majkl
RU2708336C2
IMMUNOGLOBULINS 2005
  • Ehshmehn Klehr
  • Kehssidi Martin Dzhon
  • Ehllis Dzhonatan Genri
  • Uottehm Trevor Ehntoni Kennet
RU2404192C2
TETRAVALENT ANTIBODIES TO PSGL-1 AND THEIR APPLICATIONS 2017
  • Lin, Rong-Khva
  • Lin, Shikh-Yao
  • Tsaj, Yu-In
RU2766000C2
MONOCLONAL ANTIBODIES BINDING WITH hGM-CSF AND COMPOSITIONS FOR MEDICINAL PURPOSES, CONTAINING THEREOF 2008
  • Kenzo Takada
  • Kantou Nakadzhima
  • Barbara Kistler
  • Dzhon Park
RU2517596C2
PROTEINS BINDING SPECIFIC MEMBRANE PROSTATE ANTIGEN, AND RELATED COMPOSITIONS AND METHODS 2012
  • Blankenship Dzhon V.
  • Sevell Elejn Todd
  • Tan Filip
RU2632647C2
MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN-31 2012
  • Bammert Gary F.
  • Dunham Steven A.
RU2588462C2
ANTIBODIES AGAINST A2 TENASTIN-C AND METHODS FOR USE THEREOF 2011
  • Frajmozer-Grundshober Anna
  • Khosse Ralf
  • Kljajn Kristian
  • Messner Ekkekhard
  • Nikolini Valerija G.
  • Umana Pablo
RU2584597C2

RU 2 447 084 C2

Authors

Laval'E Ehdvard Rolan

Kollinz-Rejsi Liza Anna

Korkoran Kristofer Dzhon

Chistjakova Ljudmila Gennad'Evna

Novak Dzhon Adam

Karim Rijez

Tan Ksiang-Jang

Markett Kimberli Ann

Veldman Gertruda Makteld

Dates

2012-04-10Published

2008-10-31Filed