FIELD: biotechnology.
SUBSTANCE: present invention refers to immunology and biotechnology. There are presented antibodies to A2 tenastin-C (TNC A2) domain, as well as isolated polynucleotide, expression vector, host cell and methods for producing antibody according to invention. Besides, invention refers to pharmaceutical composition and using antibody under invention for making or medicinal agent, including used for treating disease characterized by TNC A2 or for induction of cytolysis of tumour cells or stromal tumour cells.
EFFECT: present invention can find further application in therapy and diagnosis of various diseases related to TNC A2.
36 cl, 8 dwg, 8 tbl, 11 ex
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