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2 448 709

(13)

(51)

IPC

A61K31/485(2006-01-01)

C07D489/02(2006-01-01)

C07D489/08(2006-01-01)

(21) (22)

Application

2011103605/15, 2011-02-01

(24)

Start date

2011-02-01

(22)

Actual filing date

2011-02-01

(45)

Published

2012-04-27

(72)

Inventor

Kalashnikov Aleksandr IvanovichSysoljatin Sergej ViktorovichTolstikov Genrikh AleksandrovichShul'Ts Ehl'Vira EhduardovnaChernov Anatolij IvanovichBubelo Vladimir Dmitrievich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Problem Khimiko-Ehnergeticheskikh Tekhnologij Sibirskogo Otdelenija Ran So Ran)

METHOD FOR MAKING NALTREXONE Russian patent published in 2012 - IPC A61K31/485 C07D489/02 C07D489/08

Abstract RU 2448709 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly a method for making the oxymorphone derivative naltrexone being an opiate antagonist by naltrexone processing by diazomethane in the presence of palladium acetate.

EFFECT: method eliminates using hardly accessible and expensive parent compounds, and it is characterised by ease of implementation.

3 ex

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RU 2 448 709 C1

Authors

Kalashnikov Aleksandr Ivanovich

Sysoljatin Sergej Viktorovich

Tolstikov Genrikh Aleksandrovich

Shul'Ts Ehl'Vira Ehduardovna

Chernov Anatolij Ivanovich

Bubelo Vladimir Dmitrievich

Dates

2012-04-27—Published

2011-02-01—Filed