METHODS OF SYNTHESIS OF 14- HYDROXYNORMORPHINONES, INTERMEDIATE COMPOUNDS Russian patent published in 2002 - IPC

Abstract RU 2183636 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes methods of synthesis of 14-hydroxymorphinones including oxycodone, noroxymorphone, naltrexone by oxidation of normorphinone dienol acylates using an aqueous medium in the presence of a weak acid. Noroxymorphone is a key intermediate product used for synthesis of some analgetics and antagonists of narcotic substances. Also, invention describes novel intermediate compounds. EFFECT: improved methods of synthesis. 24 cl, 8 sch, 47 ex

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RU 2 183 636 C2

Authors

Khuang Bao Shan

Khristodoulu Aris

Lu Jansong

Dzhi Ben-Ij

Dates

2002-06-20—Published

1998-07-10—Filed