PHOSPHOLIPID THERAPEUTIC COMPOSITION WITH NANO-SIZED PARTICLES FOR LIPID STORAGE DISEASE AND COMATOSE STATES AND METHOD FOR PREPARING IT Russian patent published in 2012 - IPC A61K31/683 A61P3/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, and concerns a composition and a technology of finished dosage forms of phospholipid nanoparticles of the size of 25 nm. The preparation is intended for oral administration for the purpose of therapy of lipid storage disease as a hypocholesterolemic agent. An infusion form is presented to be applied in injections in therapy of toxic and pre-comatose states. The phospholipid therapeutic composition for lipid storage disease and hepatic comatose and pre-comatose state in the form of the phospholipid nanoparticles of the size of 15-25 nm contains phosphatidyl choline, phosphatidyl ethanolamine and maltose. A method for making said phospholipid therapeutic composition consists in the fact that phospholipid, phosphatidyl ethanolamine and maltose are suspended in water, and the prepared suspension is exposed to a number of microfluidisation cycles at pressure 1700-1900+10% bar, temperature 40-55°C to be lyophilised.

EFFECT: preparations represent long stored lyophilised powders.

4 cl, 3 ex, 3 tbl