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2 411 935

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IPC

A61K9/127(2006-01-01)

A61K31/704(2006-01-01)

A61K31/685(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009131864/15, 2009-08-25

(24)

Start date

2009-08-25

(22)

Actual filing date

2009-08-25

(45)

Published

2011-02-20

(72)

Inventor

Archakov Aleksandr IvanovichIpatova Ol'Ga MikhajlovnaMedvedeva Natal'Ja VelorikovnaProzorovskij Vladimir NikolaevichTorkhovskaja Tat'Jana IvanovnaTikhonova Elena GeorgievnaZykova Marija GennadievnaVoskresenskaja Anna Aleksandrovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Nauchno-Issledovatel'Skij Institut Biomeditsinskoj Khimii Im. V.N. Orekhovicha Ramn Ramn)

PHARMACEUTICAL COMPOSITION BASED ON DOXORUBICINE AND PHOSPHOLIPID NANOPARTICLES FOR TREATMENT OF ONCOLOGIC DISEASES Russian patent published in 2011 - IPC A61K9/127 A61K31/704 A61K31/685 A61P35/00

Abstract RU 2411935 C1

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, in particular to pharmaceutical composition for treatment of oncologic diseases in form of phospholipid nanoparticles with size 10-30 nm, which includes phosphatidelcholin, maltose and doxorubicine with the following ratio of components, wt. %: phosphatidelcholin 20-43, maltose 55-78, doxorubicine 2-8. Composition is accumulates in tumour tissue more actively and slows down tumour growth in mice with carcinoma LLC more efficiently in comparison with free doxorubicine.

EFFECT: composition represents freeze-dries powder, stable in long storage, which dissolving in water gives nanophpospholipid particles with included doxorubicine.

3 dwg, 5 tbl

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RU 2 411 935 C1

Authors

Archakov Aleksandr Ivanovich

Ipatova Ol'Ga Mikhajlovna

Medvedeva Natal'Ja Velorikovna

Prozorovskij Vladimir Nikolaevich

Torkhovskaja Tat'Jana Ivanovna

Tikhonova Elena Georgievna

Zykova Marija Gennadievna

Voskresenskaja Anna Aleksandrovna

Dates

2011-02-20—Published

2009-08-25—Filed