ORALLY DISPERSED DOMPERIDONE TABLETS Russian patent published in 2012 - IPC A61K31/454 A61K31/485 A61K31/451 A61K31/5415 A61K47/12 A61K47/26 A61K47/36 A61K47/38 A61K9/20 A61J3/10 A61P1/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to an orally dispersed tablet containing: max. 15 wt % of a low-dose therapeutically active substance selected from domperidone, mequitazine, codeine (base) and loperamide hydrochloride, 55 wt % to 70 wt % of mannitol of particle size of 30 mcm to 300 mcm; min. 2 % of maltodextrine; 3.5 wt % to 8 wt % of sodium croscarmellose; 10 wt % to 20 wt % of microcrystalline cellulose; 0.5 wt % to 1.5 wt % of magnesium stearate; and 1 wt % to 5 wt % of a corrective (correctives) and sweetener (sweeteners). A tablet is presented in the form of a combination of internal and external phases. The internal phase contains said therapeutically active substance, mannitol, maltodextrine and approximately a half of sodium croscarmellose. The external phase contains approximately a half of sodium croscarmellose, microcrystalline cellulose, magnesium stearate, and also correctives and sweeteners. The tablets are applied for nausea and vomiting.

EFFECT: dispersed tablets under the invention are orally decomposed for 20-40 s, have low fragility and sufficient strength.

17 cl, 4 ex