FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical composition with film coating, which contains 5'-deoxy-5-fluor-N-[(pentyloxy)carbonyl] cytidine (capecitabine) and at least one disintegrating agent, selected from group, including crospovidone (with particle size < 15-400 mcm), sodium croscarmellose, starch sodium glycolate, unsubstituted hydroxypropylcellulose, Pharmaburst C or any their combination, in combination with other pharmaceutically acceptable excipients such as binding substances, filling agents, lubricating substances, sweetening substances and flavours. Pharmaceutical composition is intended for quickly-disintegrating tablet.
EFFECT: tablet disintegrates in water at 37°C in device for carrying out USP-test for disintegration of drug forms within less than 2 min, preferably less than within 1 min, and possesses hardness, constituting 8-13 units of hardness by Cobb scale.
42 cl, 4 tbl, 18 ex
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