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2 449 995

(13)

(51)

IPC

C07D239/88(2006-01-01)

A61K31/517(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2010112450/04, 2005-06-08

(24)

Start date

2005-06-08

(22)

Actual filing date

2005-06-08

(45)

Published

2012-05-10

(72)

Inventor

Ritchi Timoti DzhonKalsho Ehndr'Ju DzhejmsBrejn Kristofer TomasDzjadulevich Ehduard KarolKhart Terens

(73)

Holder

Novartis Ag

QUINAZOLINONE DERIVATIVES EFFECTIVE AS VANILLOID ANTAGONISTS Russian patent published in 2012 - IPC C07D239/88 A61K31/517 A61P29/00

Abstract RU 2449995 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to applying a quinazolinone compound of formula: wherein R₃ has the values presented in the description and the patent claim, in the free form or in the form of salt. Also, the invention refers to a pharmaceutical composition exhibiting vanilloid receptor antagonist activity on the basis of said compounds.

EFFECT: there are produced new compounds and pharmaceutical composition on their basis which can find application in medicine for treating and preventing pain, gastrointestinal disorder.

12 cl, 30 ex

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RU 2 449 995 C2

Authors

Ritchi Timoti Dzhon

Kalsho Ehndr'Ju Dzhejms

Brejn Kristofer Tomas

Dzjadulevich Ehduard Karol

Khart Terens

Dates

2012-05-10—Published

2005-06-08—Filed