SUBSTITUTED PYRAZOLOPYRIMIDINES, METHOD FOR PREPARING AND USING THEM AS DRUG Russian patent published in 2012 - IPC C07D487/04 C07D217/02 C07D217/26 C07D401/04 C07D491/56 A61K31/519 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to substituted pyrazolopyrimidines derivatives of formula , wherein Y¹, Y², Y³, Y⁴ represent N or C-, wherein at least, two groups of Y¹-Y⁴ represent carbon atom, R¹ represents chlorine or bromine, R²-R⁷ represent, e.g. hydrogen, methyl or ethyl; and R¹⁰ and R¹¹ independently represent, e.g. hydrogen or C₁-C₆alkyl, their optical isomers and pharmaceutically acceptable salts. Also, the invention refers to using said compounds for treating and preventing a number of acute and chronic mGluR5 related neurological disorders, such as, e.g. pains of various character, dyskinesia, Parkinson's disease, anxiety disorder, Alzheimer's disease and others, a pharmaceutical composition containing specified compounds and methods for preparing them.

EFFECT: compounds are strong mGluR5 modulators.

21 cl, 2 tbl, 274 ex