HETEROBICYCLO-SUBSTITUTED-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES Russian patent published in 2018 - IPC C07D487/04 C07D495/04 C07D498/04 C07D513/04 A61K31/4985 A61K31/519 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to a compound of formula GI or pharmaceutically acceptable salts thereof. In formula GI W is a nitrogen or carbon atom; m is 1, 2, 3 or 4; n is an integer from 0 to 4, where the sum of n+m is at least 2 to 4, and where, if W is N, m is at least 2; groups from G^d1 to G^d4 independently represent a hydrogen atom or a C_1-6-alkyl; p equals 1 or 2; X, Y and Z together with W and the carbon atom to which they are attached form a (5-6)-membered aromatic or heteroaromatic moiety and independently represent: (a) -(R^G1)C=, (b) >NR^G2, (c) -N=; (d) -O- or (e) -S-; R^G3 is a moiety of the structure Values of other radicals are given in the patent claim. Invention also relates to individual compounds, to a pharmaceutical composition, to use of the compound in the manufacture of a medicament, to a method for treating Parkinson's disease. Formula GI.

EFFECT: new compounds of formula GI, which possess properties of the agonist of the receptor A_2A.

27 cl, 24 tbl, 17 ex