SPARC-DERIVATIVE ANTIGENIC PEPTIDES CAUSING TUMOUR REJECTION AND MEDICATIONS CONTAINING SUCH PEPTIDES Russian patent published in 2012 - IPC A61K39/00 A61P35/00 C07K16/18 C07K14/705 C12N5/00 

Abstract RU 2451521 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to biotechnology. Described is a peptide capable to induce cytotoxic (killer)T-cells. Presented are medications containing the described peptide that are intended for induction of immunity against malignant tumours, for tumours treatment and/or prevention, for induction of antigen-presenting cells highly capable to induce tumour-reactive T-cells and for induction of tumour-reactive T-cells. Presented is an antibody specifically bonded to the described peptide. Described are an extracted tumour-reactive killer T-cell that is induced in vitro by way of stimulation by the described peptide, a tumour-reactive helper T-cell induced in vitro by way of stimulation by the described peptide, an antigen-presenting cell representing a complex of an HLA molecule and the described peptide.

EFFECT: invention allows to intensify immunity with a patient suffering from metastasis cancer or resistant cancer when surgery treatment, chemotherapy and radiation therapy are practically inapplicable.

10 cl, 4 dwg, 1 tbl, 3 ex

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Authors

Nisimura Jasukharu

Ikuta Josiaki

Nakatsuru Suiti

Dates

2012-05-27Published

2007-06-15Filed