CDC45L PEPTIDES AND VACCINES CONTAINING SAME Russian patent published in 2015 - IPC C07K7/06 C12N15/12 C12N5/78 A61K38/08 A61P35/00 C12N15/63 

FIELD: medicine.

SUBSTANCE: present invention refers to immunology. What is presented is a recovered peptide representing a fragment of CDC45L protein and having an ability to induce cytotoxic T-lymphocytes in the form of a complex with HLA-A*2402 or HLA-A*0201 molecule. There are also disclosed a polynucleotide coding the peptide according to the invention; a composition for inducing cytotoxic lymphocyte (CD8-positive T-cell, CTL) in the presence of an antigen-presenting cell (APC); a pharmaceutical composition for treating and/or preventing CDC45L-expressing tumours and/or preventing their postoperative recurrences; methods for inducing APC and CTL; the recovered APC, which represents a complex of HLA-antigen and the peptide according to the invention on its surface; a method for inducing CDC45L-expressing cancer in the individual; an expression vector of the peptide according to the invention and the host cell transformed or transfected thereby; as well as using the peptide according to the invention and APC in producing the pharmaceutical composition for treating or preventing CDC45L-expressing tumours.

EFFECT: given invention can find further application in treating oncological diseases.

16 cl, 8 dwg, 2 tbl