SUBSTITUTED HYDRATED TIENO-PYRROLO [3,2-c] PYRIDINES, LIGANDS, PHARMACEUTICAL COMPOSITION AND ITS APPLICATION METHOD Russian patent published in 2012 - IPC C07D495/14 C07D495/22 A61K31/439 A61K31/4365 A61P25/24 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to new substituted tertahydro-4H-tieno-pyrrolo[3,2- c] pyridines of general formula 1, their geometric isomers or a mixture whereof and their pharmaceutically acceptable salts. In the general formula 1 Th represents an annulated tien cycle; W represents an single bond (in this case R3 is immediately bonded to the pyrrole cycle nitrogen atom), methylene, 1,2-ethane, 1,2-ethylene, 1,2-acetylene, 1,3-propane or 1,3-allyl bridge, non-obligatorily substituted by a hydroxy group; R1 and R2 represent hydrogen, C₁-C₄alkyl, a halogen or -CH₂OH; R3 represents hydrogen, non-obligatorily substituted phenyl, non-obligatorily substituted by azaheteroaryl; R4 represents C₁- C₄alkyl, CO₂C₂H₅ or CO₂C(CH₃)₃; R5, R6, R7 (independent of each other) represent hydrogen or C₁- C₄alkyl or R5 and R6 together form an ethylene bridge while R7 represents hydrogen or R5 and R7 together form an ethylene bridge while R6 represents a hydrogen atom, they representing substituted tetrahydro-4H-tieno-pyrrolo [3,2-c] pyridines pf general formula 1, their geometric isomers, a mixture of such geometric isomers, their pharmaceutically acceptable salts as per any of Items 1-5.

EFFECT: obtainment of compounds representing ligands with receptor activity with regard to alpha-oadrenoreceptors, dopamine receptors, histamine receptors and serotonin receptors which compounds may be used during prevention and treatment of central nervous system diseases and for study of peculiarities of physiologically active substances possession biological activity with regard to the said receptors.

11 cl, 3 tbl, 21 ex