FIELD: medicine.
SUBSTANCE: there are offered: there are offered: an agonist antibody or its functionally active fragment which specifically bind to an epitope containing the first domain Lin 12 Notch3 and activate the signal pathway Notch3. What is described is a labelled antibody and a humanised antibody of their basis. There are offered: a coding nucleic acid, a cell for producing the antibody containing said NA, as well as an expression vector. What is described is a method for producing the antibody by cell cultivation. What is disclosed is applying the antibody for preparing a drug for treating a Notch3-associated disease or disorder. What is described is applying the antibody for diagnosing the Notch3-associated disease or disorder.
EFFECT: use of the invention can find application in medicine in treating and diagnosing the CADASIL diseases.
26 cl, 11 dwg, 6 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
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