FIELD: biotechnology.
SUBSTANCE: antibodies are proposed that specifically bind to Notch1. Also, nucleic acids that encode said antibodies, vectors, host cells and methods for producing antibodies are proposed. In addition, the invention relates to a pharmaceutical composition comprising these antibodies and methods for treating disorders, mediated from Notch1, by said antibodies or a pharmaceutical composition containing them.
EFFECT: invention can be used in therapy against Notch1 for the treatment of cancer.
27 cl, 30 dwg, 45 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2580029C2 |
| ANTIBODIES AGAINST MYELIN-ASSOCIATED GLYCOPROTEIN (MAG) | 2003 |
|
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|
RU2476443C2 |
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|
RU2461569C2 |
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|
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| HUMANISED MONOCLONAL ANTIBODY SPECIFIC TO SYNDECAN-1 | 2013 |
|
RU2551235C2 |
| HUMANISED 5D3HU ANTIBODY BINDING TO THE PRAME TUMOUR ANTIGEN, DNA FRAGMENTS ENCODING SAID ANTIBODY, AND ANTIGEN-BINDING FRAGMENT OF THE ANTIBODY | 2020 |
|
RU2761876C1 |
| HUMANIZED ANTIBODY 6H8HU, BINDING TO TUMOUR ANTIGEN PRAME, DNA FRAGMENTS CODING SAID ANTIBODY AND ANTIGEN-BINDING ANTIBODY FRAGMENT | 2020 |
|
RU2768737C1 |
| ANTI-OSTEOPANTINE RECOMBINANT ANTIBODY AND USES THEREOF | 2002 |
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RU2305111C2 |
| ANTIBODIES CAPABLE OF BINDING TO HUMAN CANNABINOID RECEPTOR 1 (CB1) | 2016 |
|
RU2727018C1 |
