FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. An antibody specifically binding to semaphorin-4D (SEMA4D) has been proposed. A conjugate, composition and method for the treatment of diseases associated with SEMA4D pathology, including autoimmune diseases, inflammatory diseases, cancer, neuroinflammatory disorders and neurodegenerative diseases, including antibody, are also proposed. In addition, the invention relates to polynucleotides encoding the specified antibody, expression vectors and host cells for the production of antibodies and conjugates.
EFFECT: group of inventions provides an expansion of the arsenal of tools for the treatment of diseases associated with SEMA4D pathologies.
46 cl, 8 dwg, 4 tbl, 4 ex
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