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2 464 264

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IPC

C07D251/34(2006-01-01)

(21) (22)

Application

2011115634/04, 2011-04-21

(24)

Start date

2011-04-21

(22)

Actual filing date

2011-04-21

(45)

Published

2012-10-20

(72)

Inventor

Kazakov Pavel Vasil'EvichLukashov Oleg IvanovichMirzabekova Natal'Ja SergeevnaSokolova Nadezhda Aleksandrovna

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchno-Issledovatel'Skij Institut Organicheskoj Khimii I Tekhnologii"

METHOD OF PRODUCING 1,3,5-TRIS-(2'DIETHYLBENZYL AMMONIOETHYL)-1,3,5-TRIAZINE-2,4,6-TRIONE TRIBROMIDE Russian patent published in 2012 - IPC C07D251/34

Abstract RU 2464264 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 1,3,5-tris-(2'diethylbenzyl ammonioethyl)-1,3,5-triazine-2,4,6-trione tribromide (isociuronium bromide), a nondepolarising muscle relaxant used in medicine and veterinary. The method, which is based on use of readily available material, involves reaction of cyanuric chloride with 2-diethylaminoethanol in the presence of a hydrogen chloride acceptor: 2-diethylaminoethanol or aqueous solutions of inorganic bases, and the obtained 1,3,5-tris-(2'-diethylaminoethyl)-1,3,5-triazine-2,4,6-trione is separated via vacuum distillation and then quaternised with benzyl bromide.

EFFECT: method is easily realised in industrial conditions and enables to obtain the end product with high output and purity.

4 cl, 6 ex

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RU 2 464 264 C1

Authors

Kazakov Pavel Vasil'Evich

Lukashov Oleg Ivanovich

Mirzabekova Natal'Ja Sergeevna

Sokolova Nadezhda Aleksandrovna

Dates

2012-10-20—Published

2011-04-21—Filed