FIELD: medicine.
SUBSTANCE: invention refers to a combination applicable for pain management, such as inflammatory pain, neuropathic pain, acute pain, chronic pain, visceral pain, migraine, cancer-associated pain. The combination contains: (a) at least one 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol of formula (I), 
optionally in the form of one of its individual stereoisomers, racemates or mixed stereoisomers, or in the form of a pharmaceutically acceptable acid-additive salt, or in the form of its solvate in the effective amount, and (b) one or more non-steroid anti-inflammatory preparations (NSAIP) specified in a group consisting of diclofenac, diclofenac sodium salt, metamizol, metamizol sodium salt, ibuprofen, ketoprofen, naproxen, (+)-ibuprofen, (-)-ibuprofen, (+)-naproxen in the effective amount. The ingredients of the combination may be introduced either simultaneously, or sequentially: the compound (a) is introduced before or after the compound (b) by the same or different methods. The invention also refers to a pharmaceutical salt formed by a cationic ingredient (a) of 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol of formula (I) and an anionic ingredient (b) of the acid non-steroid anti-inflammatory preparation (NSAIP) as well as to the compound of general formula (I") wherein the phenol hydroxyl group of the compound a) and the carboxyl group of the NSAIP forms a covalent bond.
EFFECT: higher clinical effectiveness of the combination.
29 cl, 2 tbl, 21 ex
