FIELD: medicine, pharmaceutics.
SUBSTANCE: given invention refers to a sustained-release tapentadol composition also containing a second active agent, wherein the above second active agent is specified in tramadol, pregabalin, gabapentyl, or pharmaceutically acceptable salts thereof. The given composition may be used to prepare a therapeutic agent for pain management. Besides, the present invention refers to a method of managing pain and conditions related to pain, by administering the given composition. The given invention also refers to a kit including a sustained-release tapentadol formulation also containing the second active agent, wherein the above second active agent is specified in tramadol, pregabalin, gabapentyl or pharmaceutically acceptable salts thereof.
EFFECT: reducing side effects.
15 cl, 19 tbl, 16 ex, 6 dwg
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