TRICHODERMA HARZIANUM M 99/51 MICROMYCETE STRAIN USED AS PRODUCER FOR PREPARING BIOLOGICALLY ACTIVE ANTICANCER PREPARATIONS Russian patent published in 2012 - IPC C12N1/14 A61K36/06 A61P35/00 

FIELD: medicine.

SUBSTANCE: what is offered is the Trichoderma harzianum rifai M 99/51 strain deposited in the Russian National Collection of Industrial Microorganisms, No. F-1027. The strain is characterised by synthesis of active anticancer non-peptide compounds having no amide bonds. Besides, the strain is marked by producing the anticancer compounds. The strain has high cytotoxic activity with respect to the anticancer cell lines (human HaCaT-keratinocytes; THP-1 macrophage-like human cell line; A431 - human epidermoid carcinoma line; JurKat - human T-cells; K562 - chronic myeloid leukemia cell line; HEK293T - human embryonic kidney cells) and may be used for producing anticancer preparations.

EFFECT: using this strain as a producer for making the based anticancer preparations.

8 dwg, 6 ex