METHOD OF OBTAINING PHOSPHONOMETHYL-SUBSTITUTED PHTHALOCYANINES Russian patent published in 2012 - IPC A61K31/675 A61K31/40 C07D487/22 

Abstract RU 2465908 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to method of obtaining phosphonomethyl-substituted phthalocyanines, which consists in interaction of chlormethyl-substituted phthalocyanons with phosphorylating agent - phosphorus trichloride with the following hydrolysis of reaction product in water, water-alkaline or acid-mixture solution. Interaction is carried out in presence of aluminium chloride and tertiary amine at temperature 70-80°C for 2-20 hours.

EFFECT: method ensures increase phosphorylation safety and increased yield of phosphonomethyl-substituted phthalocyanines.

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Authors

Juzhakova Ol'Ga Alekseevna

Komissarov Aleksej Nikolaevich

Negrimovskij Vladimir Mikhajlovich

Luk'Janets Evgenij Antonovich

Kuznetsova Nina Aleksandrovna

Dates

2012-11-10Published

2011-07-06Filed